Tokai University School of Medicine, Department of Molecular Life Science
Genomic instability is a hallmark of cancer, promoting malignancy by increasing the accumulation of mutations. Major causes of genomic instability in cancer are abnormalities in DNA repair and DNA damage response (DDR). Interestingly, such abnormalities can also make cancer cells more sensitive to certain chemotherapeutic agents.
To better understand cancer and develop improved strategies for its diagnosis and treatment, our laboratory is working to:
We are particularly interested in the following pathways: